Water Networks Contribute to Enthalpy/Entropy Compensation in Protein–Ligand Binding
نویسندگان
چکیده
منابع مشابه
Water networks contribute to enthalpy/entropy compensation in protein-ligand binding.
The mechanism (or mechanisms) of enthalpy-entropy (H/S) compensation in protein-ligand binding remains controversial, and there are still no predictive models (theoretical or experimental) in which hypotheses of ligand binding can be readily tested. Here we describe a particularly well-defined system of protein and ligands--human carbonic anhydrase (HCA) and a series of benzothiazole sulfonamid...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2013
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja4075776